Peptic ulcer disease (PUD) is a condition that causes peptic ulcers. There are two main types of peptic ulcers: gastric and duodenal ulcers. Many people with peptic ulcer disease may not experience any symptoms. Common symptoms include upper abdominal (epigastric) discomfort or pain, indigestion, heartburn, nausea, etc. Contact your healthcare provider if you have PUD symptoms.